Histone deacetylase inhibition decreases proliferation and potentiates the effect of ionizing radiation in atypical teratoid/rhabdoid tumor cells

Atypical teratoid/rhabdoid tumor (ATRT) is a highly malignant central nervous system neoplasm that primarily occurs in children less than 3 years of age. Because of poor outcomes with intense and toxic multimodality treatment, new therapies are urgently needed. Histone deacetylase inhibitors (HDIs)...

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Main Authors: Knipstein, Jeffrey A., Birks, Diane K., Donson, Andrew M., Alimova, Irina, Foreman, Nicholas K., Vibhakar, Rajeev
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Basic and Translational Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266389/
https://ncbi.nlm.nih.gov/pubmed/22156471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor208
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