PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain

BACKGROUND: Chronic pain occurs when normally protective acute pain becomes pathologically persistent. We examined here whether an isoform of protein kinase C (PKC), PKMζ, that underlies long-term memory storage in various brain regions, also sustains nociceptive plasticity in spinal cord dorsal hor...

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Détails bibliographiques
Auteurs principaux: Laferrière, Andre, Pitcher, Mark H, Haldane, Anne, Huang, Yue, Cornea, Virginia, Kumar, Naresh, Sacktor, Todd C, Cervero, Fernando, Coderre, Terence J
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2011
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266216/
https://ncbi.nlm.nih.gov/pubmed/22185613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-99
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