Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control

BACKGROUND: Toxins A and B (TcdA and TcdB) are Clostridium difficile's principal virulence factors, yet the pathways by which they lead to inflammation and severe diarrhea remain unclear. Also, the relative role of either toxin during infection and the differences in their effects across cell l...

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Hauptverfasser: D'Auria, Kevin M, Donato, Gina M, Gray, Mary C, Kolling, Glynis L, Warren, Cirle A, Cave, Lauren M, Solga, Michael D, Lannigan, Joanne A, Papin, Jason A, Hewlett, Erik L
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266197/
https://ncbi.nlm.nih.gov/pubmed/22225989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-6-2
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