Successful Microbubble Sonothrombolysis without Tissue Plasminogen Activator in a Rabbit Model of Acute Ischemic Stroke

BACKGROUND: Microbubbles (MB) combined with ultrasound (US) have been shown to lyse clots without tissue plasminogen activator (tPA) both in vitro and in vivo. We evaluated sonothrombolysis with three types of MB using a rabbit embolic stroke model. METHODS: New Zealand White rabbits (n=74) received...

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Detalhes bibliográficos
Main Authors: Culp, William C., Flores, Rene, Brown, Aliza T., Lowery, John D., Roberson, Paula K., Hennings, Leah J., Woods, Sean D., Hatton, Jeff H., Culp, Benjamin C., Skinner, Robert D., Borrelli, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266124/
https://ncbi.nlm.nih.gov/pubmed/21700942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.110.607150
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