Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency

Whole-exome sequencing (Exome-seq) has been successfully applied in several recent studies. We here sequenced the exomes of 15 pancreatic tumor cell lines and their matched normal samples. We captured 162,073 exons of 16,954 genes and sequenced the targeted regions to a mean coverage of 56-fold. Thi...

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Detalhes bibliográficos
Main Authors: Wang, Linghua, Tsutsumi, Shuichi, Kawaguchi, Tokuichi, Nagasaki, Koichi, Tatsuno, Kenji, Yamamoto, Shogo, Sang, Fei, Sonoda, Kohtaro, Sugawara, Minoru, Saiura, Akio, Hirono, Seiko, Yamaue, Hiroki, Miki, Yoshio, Isomura, Minoru, Totoki, Yasushi, Nagae, Genta, Isagawa, Takayuki, Ueda, Hiroki, Murayama-Hosokawa, Satsuki, Shibata, Tatsuhiro, Sakamoto, Hiromi, Kanai, Yae, Kaneda, Atsushi, Noda, Tetsuo, Aburatani, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266029/
https://ncbi.nlm.nih.gov/pubmed/22156295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.123109.111
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