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Addition of N-terminal peptide sequences activates the oncogenic and signaling potentials of the catalytic subunit p110α of phosphoinositide-3-kinase

Addition of short (6 to 16 amino acids) peptide sequences to the N-terminus of p110α induces a gain of function. Such sequences include the common Flag, His and VSV tags as well as random sequences. An N-terminal myristylation signal generally believed to activate p110α by providing a constitutive m...

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Bibliografske podrobnosti
Main Authors: Sun, Minghao, Hart, Jonathan R, Hillmann, Petra, Gymnopoulos, Marco, Vogt, Peter K
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266008/
https://ncbi.nlm.nih.gov/pubmed/22045127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.21.17920
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