Sh3rf2/POSHER Protein Promotes Cell Survival by Ring-mediated Proteasomal Degradation of the c-Jun N-terminal Kinase Scaffold POSH (Plenty of SH3s) Protein

We report that Sh3rf2, a homologue of the pro-apoptotic scaffold POSH (Plenty of SH3s), acts as an anti-apoptotic regulator for the c-Jun N-terminal kinase (JNK) pathway. siRNA-mediated knockdown of Sh3rf2 promotes apoptosis of neuronal PC12 cells, cultured cortical neurons, and C6 glioma cells. Thi...

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Main Authors: Wilhelm, Michael, Kukekov, Nickolay V., Schmit, Travis L., Biagas, Katherine V., Sproul, Andrew A., Gire, Stephen, Maes, Margaret E., Xu, Zhiheng, Greene, Lloyd A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265902/
https://ncbi.nlm.nih.gov/pubmed/22128169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.269431
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