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Skp1 Prolyl 4-Hydroxylase of Dictyostelium Mediates Glycosylation-independent and -dependent Responses to O(2) without Affecting Skp1 Stability

Cytoplasmic prolyl 4-hydroxylases (PHDs) have a primary role in O(2) sensing in animals via modification of the transcriptional factor subunit HIFα, resulting in its polyubiquitination by the E3(VHL)ubiquitin (Ub) ligase and degradation in the 26 S proteasome. Previously thought to be restricted to...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Dongmei, van der Wel, Hanke, Johnson, Jennifer M., West, Christopher M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265880/
https://ncbi.nlm.nih.gov/pubmed/22128189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.314021
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