The Skp1 Protein from Toxoplasma Is Modified by a Cytoplasmic Prolyl 4-Hydroxylase Associated with Oxygen Sensing in the Social Amoeba Dictyostelium

In diverse types of organisms, cellular hypoxic responses are mediated by prolyl 4-hydroxylases that use O(2) and α-ketoglutarate as substrates to hydroxylate conserved proline residues in target proteins. Whereas in metazoans these enzymes control the stability of the HIFα family of transcription f...

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Autors principals: Xu, Yuechi, Brown, Kevin M., Wang, Zhuo A., van der Wel, Hanke, Teygong, Crystal, Zhang, Dongmei, Blader, Ira J., West, Christopher M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408163/
https://ncbi.nlm.nih.gov/pubmed/22648409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.355446
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