Conditional ablation of the Notch2 receptor in the ocular lens

Notch signaling is essential for proper lens development, however the specific requirements of individual Notch receptors have not been investigated. Here we report the lens phenotypes of Notch2 conditionally mutant mice, which exhibited severe microphthalmia, reduced pupillary openings, disrupted f...

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Autori principali: Saravanamuthu, Senthil S., Le, Tien T., Gao, Chun Y., Cojocaru, Radu I., Pandiyan, Pushpa, Liu, Chunqiao, Zhang, Jun, Zelenka, Peggy S., Brown, Nadean L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265577/
https://ncbi.nlm.nih.gov/pubmed/22173065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2011.11.011
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