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Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens
Presenilins (Psen1 and Psen2 in mice) are polytopic transmembrane proteins that act in the γ-secretase complex to make intra-membrane cleavages of their substrates, including the well-studied Notch receptors. Such processing releases the Notch intracellular domain, allowing it to physically relocate...
Zapisane w:
| Wydane w: | Differentiation |
|---|---|
| Główni autorzy: | , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2018
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6089524/ https://ncbi.nlm.nih.gov/pubmed/30059908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.diff.2018.07.003 |
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