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Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens
Presenilins (Psen1 and Psen2 in mice) are polytopic transmembrane proteins that act in the γ-secretase complex to make intra-membrane cleavages of their substrates, including the well-studied Notch receptors. Such processing releases the Notch intracellular domain, allowing it to physically relocate...
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| Publicado no: | Differentiation |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6089524/ https://ncbi.nlm.nih.gov/pubmed/30059908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.diff.2018.07.003 |
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