Functional Characterization of MODY2 Mutations Highlights the Importance of the Fine-Tuning of Glucokinase and Its Role in Glucose Sensing

Glucokinase (GK) acts as a glucose sensor in the pancreatic beta-cell and regulates insulin secretion. Heterozygous mutations in the human GK-encoding GCK gene that reduce the activity index increase the glucose-stimulated insulin secretion threshold and cause familial, mild fasting hyperglycaemia,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: García-Herrero, Carmen-María, Rubio-Cabezas, Oscar, Azriel, Sharona, Gutierrez-Nogués, Angel, Aragonés, Angel, Vincent, Olivier, Campos-Barros, Angel, Argente, Jesús, Navas, María-Angeles
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265476/
https://ncbi.nlm.nih.gov/pubmed/22291974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030518
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg