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Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability
Glucokinase acts as the pancreatic glucose sensor and plays a critical role in the regulation of insulin secretion by the β-cell. Heterozygous mutations in the glucokinase-encoding GCK gene, which result in a reduction of the enzymatic activity, cause the monogenic form of diabetes, MODY2 (maturity-...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Portland Press Ltd.
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1383698/ https://ncbi.nlm.nih.gov/pubmed/16173921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051137 |
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