Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability

Glucokinase acts as the pancreatic glucose sensor and plays a critical role in the regulation of insulin secretion by the β-cell. Heterozygous mutations in the glucokinase-encoding GCK gene, which result in a reduction of the enzymatic activity, cause the monogenic form of diabetes, MODY2 (maturity-...

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Main Authors: Galán, María, Vincent, Olivier, Roncero, Isabel, Azriel, Sharona, Boix-Pallares, Pedro, Delgado-Alvarez, Elías, Díaz-Cadórniga, Francisco, Blázquez, Enrique, Navas, María-Angeles
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383698/
https://ncbi.nlm.nih.gov/pubmed/16173921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051137
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