Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

A major barrier to research on Parkinson's disease is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells from patients and differentiate them into neurons affected by disease. Triplication of SNCA, encoding α-synuclein, causes a fully penetran...

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Hauptverfasser: Devine, Michael J., Ryten, Mina, Vodicka, Petr, Thomson, Alison J., Burdon, Tom, Houlden, Henry, Cavaleri, Fatima, Nagano, Masumi, Drummond, Nicola J., Taanman, Jan-Willem, Schapira, Anthony H., Gwinn, Katrina, Hardy, John, Lewis, Patrick A., Kunath, Tilo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265381/
https://ncbi.nlm.nih.gov/pubmed/21863007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1453
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