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Cross-linking of DNA induced by chloroethylnitrosourea is presented by O6-methylguanine-DNA methyltransferase.

The DNA repair enzyme O6-methylguanine-DNA methyltransferase has been used as a reagent to analyse the initial reaction sites of alkylating agents such as chloroethylnitrosourea that cross-link DNA. The transferase can be employed for this purpose because it removes substituted ethyl groups from DNA...

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Udgivet i:Nucleic Acids Res
Principais autores: Robins, P, Harris, A L, Goldsmith, I, Lindahl, T
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1983
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC326526/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6359062/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/11.22.7743
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