Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling

Traditionally, GRP78 is regarded as protective against hypoxia and nutrient starvation prevalent in the microenvironment of solid tumors; thus, its role in the development of hematologic malignancies remains to be determined. To directly elucidate the requirement of GRP78 in leukemogenesis, we creat...

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Main Authors: Wey, Shiuan, Luo, Biquan, Tseng, Chun-Chih, Ni, Min, Zhou, Hui, Fu, Yong, Bhojwani, Deepa, Carroll, William L., Lee, Amy S.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2012
Teme:
Myeloid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265205/
https://ncbi.nlm.nih.gov/pubmed/21937694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-357384
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