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Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH

The MUC1-C oncoprotein is aberrantly expressed in most multiple myeloma cells. However, the functional significance of MUC1-C expression in multiple myeloma is not known. The present studies demonstrate that treatment of multiple myeloma cells with a MUC1-C inhibitor is associated with increases in...

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Detalhes bibliográficos
Main Authors: Yin, Li, Kosugi, Michio, Kufe, Donald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265204/
https://ncbi.nlm.nih.gov/pubmed/22117045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-369686
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