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Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases

Class I aminoacyl-tRNA synthetases (aaRSs) use a Rossmann-fold domain to catalyze the synthesis of aminoacyl-tRNAs required for decoding genetic information. While the Rossmann-fold domain is conserved in evolution, the acceptor stem near the aminoacylation site varies among tRNA substrates, raising...

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Detalhes bibliográficos
Main Authors: Liu, Cuiping, Sanders, Jeffrey M., Pascal, John M., Hou, Ya-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264908/
https://ncbi.nlm.nih.gov/pubmed/22184460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.029983.111
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