Dicer-substrate siRNA inhibits tumor necrosis factor alpha secretion in Kupffer cells in vitro: In vivo targeting of Kupffer cells by siRNA-liposomes

Tumor necrosis factor alpha (TNF-α) plays a major role in the pathogenesis of many inflammatory diseases. Neutralizing TNF-α by antibodies or antisense oligodeoxynucleotides, alleviate disease symptoms. In this study, we introduce the new generation of gene-silencing molecules, namely the small inte...

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Hlavní autoři: Pichu, Sivakamasundari, Krishnamoorthy, Swapna, Zhang, Bi, Jing, Yawu, Shishkov, Andrei, Ponnappa, Biddanda C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264835/
https://ncbi.nlm.nih.gov/pubmed/21933712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2011.09.001
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