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GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles
The biophysical characterization of purified membrane proteins typically requires detergent mediated extraction from native lipid membrane environments. In the case of human G protein-coupled receptors (GPCRs), this process has been complicated by their conformational heterogeneity and the general l...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3264755/ https://ncbi.nlm.nih.gov/pubmed/22041719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2011.10.011 |
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