Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability

Androst-3β,5α,6β-triol (Triol) is a promising neuroprotective agent, but its poor solubility restricts its development into parenteral preparations. In this study, Triol is significantly solubilized by bile salt/phosphatidylcholine mixed micelles (BS/PC-MM). All BS/PC-MM systems are tested to remark...

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Bibliografische gegevens
Gepubliceerd in:Drug Des Devel Ther
Hoofdauteurs: Guo, Qin, Cai, Jie, Li, Pengyu, Xu, Dongling, Ni, Xiaomin, Wen, Hui, Liu, Dan, Lin, Suizhen, Hu, Haiyan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Dove Medical Press 2016
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117881/
https://ncbi.nlm.nih.gov/pubmed/27895469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S119918
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