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Protein conformational gating of enzymatic activity in xanthine oxidoreductase

In mammals, xanthine oxidoreductase can exist as xanthine dehydrogenase (XDH) and xanthine oxidase (XO). The two enzymes possess common redox active cofactors, which form an electron transfer (ET) pathway terminated by a flavin cofactor. In spite of identical protein primary structures, the redox po...

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Bibliographische Detailangaben
Hauptverfasser: Ishikita, Hiroshi, Eger, Bryan T., Okamoto, Ken, Nishino, Takeshi, Pai, Emil F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264664/
https://ncbi.nlm.nih.gov/pubmed/22145797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja207173p
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