Paraquat, but Not Maneb, Induces Synucleinopathy and Tauopathy in Striata of Mice through Inhibition of Proteasomal and Autophagic Pathways

SNCA and MAPT genes and environmental factors are important risk factors of Parkinson's disease [PD], the second-most common neurodegenerative disease. The agrichemicals maneb and paraquat selectively target dopaminergic neurons, leading to parkinsonism, through ill-defined mechanisms. In the c...

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Main Authors: Wills, Jonathan, Credle, Joel, Oaks, Adam W., Duka, Valeriy, Lee, Jae-Hoon, Jones, Jessica, Sidhu, Anita
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264632/
https://ncbi.nlm.nih.gov/pubmed/22292029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030745
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