The CD3-Zeta Chimeric Antigen Receptor Overcomes TCR Hypo-Responsiveness of Human Terminal Late-Stage T Cells

Adoptive therapy of malignant diseases with tumor-specific cytotoxic T cells showed remarkable efficacy in recent trials. Repetitive T cell receptor (TCR) engagement of target antigen, however, inevitably ends up in hypo-responsive cells with terminally differentiated KLRG-1(+) CD57(+) CD7(−) phenot...

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Bibliographische Detailangaben
Hauptverfasser: Rappl, Gunter, Riet, Tobias, Awerkiew, Sabine, Schmidt, Annette, Hombach, Andreas A., Pfister, Herbert, Abken, Hinrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264628/
https://ncbi.nlm.nih.gov/pubmed/22292024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030713
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