eNOS Protects from Atherosclerosis Despite Relevant Superoxide Production by the Enzyme in apoE(−/−) Mice

BACKGROUND: All three nitric oxide synthase (NOS) isoforms are expressed in atherosclerotic plaques. NOS enzymes in general catalyse NO production. However, under conditions of substrate and cofactor deficiency, the enzyme directly catalyse superoxide formation. Considering this alternative chemistr...

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Autori principali: Ponnuswamy, Padmapriya, Schröttle, Angelika, Ostermeier, Eva, Grüner, Sabine, Huang, Paul L., Ertl, Georg, Hoffmann, Ulrich, Nieswandt, Bernhard, Kuhlencordt, Peter J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264598/
https://ncbi.nlm.nih.gov/pubmed/22291917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030193
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