eNOS Protects from Atherosclerosis Despite Relevant Superoxide Production by the Enzyme in apoE(−/−) Mice

BACKGROUND: All three nitric oxide synthase (NOS) isoforms are expressed in atherosclerotic plaques. NOS enzymes in general catalyse NO production. However, under conditions of substrate and cofactor deficiency, the enzyme directly catalyse superoxide formation. Considering this alternative chemistr...

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Detalhes bibliográficos
Main Authors: Ponnuswamy, Padmapriya, Schröttle, Angelika, Ostermeier, Eva, Grüner, Sabine, Huang, Paul L., Ertl, Georg, Hoffmann, Ulrich, Nieswandt, Bernhard, Kuhlencordt, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264598/
https://ncbi.nlm.nih.gov/pubmed/22291917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030193
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