eNOS Protects from Atherosclerosis Despite Relevant Superoxide Production by the Enzyme in apoE(−/−) Mice

BACKGROUND: All three nitric oxide synthase (NOS) isoforms are expressed in atherosclerotic plaques. NOS enzymes in general catalyse NO production. However, under conditions of substrate and cofactor deficiency, the enzyme directly catalyse superoxide formation. Considering this alternative chemistr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ponnuswamy, Padmapriya, Schröttle, Angelika, Ostermeier, Eva, Grüner, Sabine, Huang, Paul L., Ertl, Georg, Hoffmann, Ulrich, Nieswandt, Bernhard, Kuhlencordt, Peter J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264598/
https://ncbi.nlm.nih.gov/pubmed/22291917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030193
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