RING Domain Mutations Uncouple TRIM5α Restriction of HIV-1 from Inhibition of Reverse Transcription and Acceleration of Uncoating

Rhesus TRIM5α (TRIM5α(rh)) is a cytosolic protein that potently restricts HIV-1 at an early postentry stage, prior to reverse transcription. The ability of TRIM5α(rh) to block HIV-1 infection has been correlated with a decrease of pelletable HIV-1 capsid during infection. To genetically dissect the...

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Detalhes bibliográficos
Main Authors: Roa, Amanda, Hayashi, Fumiaki, Yang, Yang, Lienlaf, Maritza, Zhou, Jing, Shi, Jiong, Watanabe, Satoru, Kigawa, Takanori, Yokoyama, Shigeyuki, Aiken, Christopher, Diaz-Griffero, Felipe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264337/
https://ncbi.nlm.nih.gov/pubmed/22114335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05811-11
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