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Contribution of E3-Ubiquitin Ligase Activity to HIV-1 Restriction by TRIM5α(rh): Structure of the RING Domain of TRIM5α
TRIM5α(rh) is a cytosolic protein that potently restricts HIV-1 before reverse transcription. TRIM5α(rh) is composed of four different domains: RING, B-box 2, coiled coil, and B30.2(SPRY). The contribution of each of these domains to restriction has been extensively studied, with the exception of th...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3165826/ https://ncbi.nlm.nih.gov/pubmed/21734049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00497-11 |
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