Contribution of E3-Ubiquitin Ligase Activity to HIV-1 Restriction by TRIM5α(rh): Structure of the RING Domain of TRIM5α

TRIM5α(rh) is a cytosolic protein that potently restricts HIV-1 before reverse transcription. TRIM5α(rh) is composed of four different domains: RING, B-box 2, coiled coil, and B30.2(SPRY). The contribution of each of these domains to restriction has been extensively studied, with the exception of th...

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Main Authors: Lienlaf, Maritza, Hayashi, Fumiaki, Di Nunzio, Francesca, Tochio, Naoya, Kigawa, Takanori, Yokoyama, Shigeyuki, Diaz-Griffero, Felipe
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2011
Ábhair:
Virus-Cell Interactions
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165826/
https://ncbi.nlm.nih.gov/pubmed/21734049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00497-11
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