Phenylethyl Butyrate Enhances the Potency of Second-Line Drugs against Clinical Isolates of Mycobacterium tuberculosis

Ethionamide (ETH) is a second-line drug for the treatment of tuberculosis. As a prodrug, ETH has to be activated by EthA. ethA is controlled by its repressor EthR. 2-Phenylethyl-butyrate (2-PEB) inhibits EthR binding, enhances expression of EthA, and thereby enhances the growth-inhibitory effects of...

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Detaylı Bibliyografya
Asıl Yazarlar: Grau, Thomas, Selchow, Petra, Tigges, Marcel, Burri, Reto, Gitzinger, Marc, Böttger, Erik C., Fussenegger, Martin, Sander, Peter
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2012
Konular:
Susceptibility
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264283/
https://ncbi.nlm.nih.gov/pubmed/22106218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05649-11
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