Interplay between Single Resistance-Associated Mutations in the HIV-1 Protease and Viral Infectivity, Protease Activity, and Inhibitor Sensitivity

Resistance-associated mutations in the HIV-1 protease modify viral fitness through changes in the catalytic activity and altered binding affinity for substrates and inhibitors. In this report, we examine the effects of 31 mutations at 26 amino acid positions in protease to determine their impact on...

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Detalhes bibliográficos
Main Authors: Henderson, Gavin J., Lee, Sook-Kyung, Irlbeck, David M., Harris, Janera, Kline, Melissa, Pollom, Elizabeth, Parkin, Neil, Swanstrom, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264268/
https://ncbi.nlm.nih.gov/pubmed/22083488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05549-11
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