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Iron Storage Proteins Are Essential for the Survival and Pathogenesis of Mycobacterium tuberculosis in THP-1 Macrophages and the Guinea Pig Model of Infection

Iron is one of the crucial elements required for the growth of Mycobacterium tuberculosis. However, excess free iron becomes toxic for the cells because it catalyzes the production of reactive oxygen radicals, leading to oxidative damage. Hence, it is essential for the pathogen to have the ability t...

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Main Authors: Reddy, P. Vineel, Puri, Rupangi Verma, Khera, Aparna, Tyagi, Anil K.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264086/
https://ncbi.nlm.nih.gov/pubmed/22101841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.05553-11
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