Glutamine Synthetase GlnA1 Is Essential for Growth of Mycobacterium tuberculosis in Human THP-1 Macrophages and Guinea Pigs

To assess the role of glutamine synthetase (GS), an enzyme of central importance in nitrogen metabolism, in the pathogenicity of Mycobacterium tuberculosis, we constructed a glnA1 mutant via allelic exchange. The mutant had no detectable GS protein or GS activity and was auxotrophic for l-glutamine....

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Tullius, Michael V., Harth, Günter, Horwitz, Marcus A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Molecular Pathogenesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162033/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12819079/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.7.3927-3936.2003
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