Glutamine Synthetase GlnA1 Is Essential for Growth of Mycobacterium tuberculosis in Human THP-1 Macrophages and Guinea Pigs
To assess the role of glutamine synthetase (GS), an enzyme of central importance in nitrogen metabolism, in the pathogenicity of Mycobacterium tuberculosis, we constructed a glnA1 mutant via allelic exchange. The mutant had no detectable GS protein or GS activity and was auxotrophic for l-glutamine....
Αποθηκεύτηκε σε:
| Εκδόθηκε σε: | Infect Immun |
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| Κύριοι συγγραφείς: | , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Microbiology (ASM)
2003
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162033/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12819079/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.7.3927-3936.2003 |
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