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Chronic Methadone Treatment Shows a Better Cost/Benefit Ratio than Chronic Morphine in Mice

Chronic treatment of pain with opiate drugs can lead to analgesic tolerance and drug dependence. Although all opiate drugs can promote tolerance and dependence in practice, the severity of those unwanted side effects differs depending on the drug used. Although each opiate drug has its own unique se...

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Autori principali: Enquist, Johan, Ferwerda, Madeline, Milan-Lobo, Laura, Whistler, Jennifer L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263965/
https://ncbi.nlm.nih.gov/pubmed/22062352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.187583
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