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A Novel Knock-In Mouse Reveals Mechanistically Distinct Forms of Morphine Tolerance

The role of μ-opioid receptor (MOR) down-regulation in opioid tolerance remains controversial. In this study, we used a novel knock-in mouse to examine how changing the extent of MOR down-regulation alters the development of morphine tolerance. These mice express a mutant MOR, degrading MOR (DMOR),...

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Main Authors: Enquist, Johan, Kim, Joseph A., Bartlett, Selena, Ferwerda, Madeline, Whistler, Jennifer L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2011
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141896/
https://ncbi.nlm.nih.gov/pubmed/21562138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.179754
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