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A Novel Knock-In Mouse Reveals Mechanistically Distinct Forms of Morphine Tolerance
The role of μ-opioid receptor (MOR) down-regulation in opioid tolerance remains controversial. In this study, we used a novel knock-in mouse to examine how changing the extent of MOR down-regulation alters the development of morphine tolerance. These mice express a mutant MOR, degrading MOR (DMOR),...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3141896/ https://ncbi.nlm.nih.gov/pubmed/21562138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.179754 |
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