Antitumor activity of SNX-2112, a synthetic heat shock protein-90 inhibitor, in MET-amplified tumor cells with or without resistance to selective MET inhibition

PURPOSE: Heat shock protein-90 (HSP-90), a molecular chaperone required by numerous oncogenic kinases (e.g. HER-2, EGFR, Raf-1, v-Src, AKT) for conformational stability, has attracted wide interest as a novel target for cancer therapy. HSP-90 inhibition induces degradation of HSP-90 client proteins,...

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Detalhes bibliográficos
Main Authors: Bachleitner-Hofmann, Thomas, Sun, Mark Y., Chen, Chin-Tung, Liska, David, Zeng, Zhaoshi, Viale, Agnes, Olshen, Adam B., Mittlboeck, Martina, Christensen, James G., Rosen, Neal, Solit, David B., Weiser, Martin R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263825/
https://ncbi.nlm.nih.gov/pubmed/21208906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0253
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