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HGF rescues colorectal cancer cells from EGFR inhibition via MET activation

PURPOSE: Cetuximab, an antibody targeting the epidermal growth factor receptor (EGFR), is active in colorectal cancer (CRC). However, response rates range from only 10% to 20%. Here, we investigate hepatocyte growth factor (HGF)-dependent mesenchymal-epithelial transition factor (MET) activation as...

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Detalhes bibliográficos
Main Authors: Liska, David, Chen, Chin-Tung, Bachleitner-Hofmann, Thomas, Christensen, James G., Weiser, Martin R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033451/
https://ncbi.nlm.nih.gov/pubmed/21098338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0568
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