SNX2112, a Synthetic Heat Shock Protein 90 Inhibitor, Has Potent Antitumor Activity against HER Kinase–Dependent Cancers

PURPOSE: The heat shock protein 90 (Hsp90) chaperone plays an important role in transformation by regulating the conformational maturation and stability of oncogenic kinases and transcription factors. Ansamycins, such as 17-(allylamino)-17-demethoxygeldanmycin (17-AAG), inhibit Hsp90 function; induc...

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Detalhes bibliográficos
Main Authors: Chandarlapaty, Sarat, Sawai, Ayana, Ye, Qing, Scott, Anisa, Silinski, Melanie, Huang, Ken, Fadden, Pat, Partdrige, Jeff, Hall, Steven, Steed, Paul, Norton, Larry, Rosen, Neal, Solit, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203688/
https://ncbi.nlm.nih.gov/pubmed/18172276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-1667
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