HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway

Hypoxia induces the expansion of glioblastoma stem cells (GSCs), but the mechanism underlying it is still unclear. Here, we supply evidence that hypoxia-inducible factor-1α (HIF-1α) induced activation of Notch pathway is essential for hypoxia-mediated maintenance of GSC. Either depletion of HIF-1α o...

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Библиографические подробности
Главные авторы: Qiang, L, Wu, T, Zhang, H-W, Lu, N, Hu, R, Wang, Y-J, Zhao, L, Chen, F-H, Wang, X-T, You, Q-D, Guo, Q-L
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2012
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Original Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263503/
https://ncbi.nlm.nih.gov/pubmed/21818118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.95
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