Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation

Telomere length is critical for chromosome stability that affects cell proliferation and survival. Telomere elongation by telomerase is inhibited by the telomeric protein, TRF1. Tankyrase-1 (TNKS1) poly(ADP-ribosyl)ates TRF1 and releases TRF1 from telomeres, thereby allowing access of telomerase to...

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Detalhes bibliográficos
Main Authors: Ha, G-H, Kim, H-S, Go, H, Lee, H, Seimiya, H, Chung, D H, Lee, C-W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263489/
https://ncbi.nlm.nih.gov/pubmed/21818122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.101
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