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Insulin-Like Growth Factor-1 Preconditioning Accentuates Intrinsic Survival Mechanism in Stem Cells to Resist Ischemic Injury by Orchestrating Protein Kinase Cα–Erk1/2 Activation

Aims: To test our hypothesis that the intrinsic molecular mechanism in stem cells for adaptation to ischemia is accentuated by preconditioning with insulin-like growth factor (IGF-1). Results: Bone marrow Sca-1(+) cells were exposed to oxygen and glucose deprivation (OGD) for up to 12 h. Erk1/2 was...

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Bibliografski detalji
Glavni autori: Lu, Gang, Ashraf, Muhammad, Haider, Khawaja Husnain
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263485/
https://ncbi.nlm.nih.gov/pubmed/21923556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4112
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