A Worldwide Analysis of Beta-Defensin Copy Number Variation Suggests Recent Selection of a High-Expressing DEFB103 Gene Copy in East Asia

Beta-defensins are a family of multifunctional genes with roles in defense against pathogens, reproduction, and pigmentation. In humans, six beta-defensin genes are clustered in a repeated region which is copy-number variable (CNV) as a block, with a diploid copy number between 1 and 12. The role in...

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Detalhes bibliográficos
Main Authors: Hardwick, Robert J, Machado, Lee R, Zuccherato, Luciana W, Antolinos, Suzanne, Xue, Yali, Shawa, Nyambura, Gilman, Robert H, Cabrera, Lilia, Berg, Douglas E, Tyler-Smith, Chris, Kelly, Paul, Tarazona-Santos, Eduardo, Hollox, Edward J
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263423/
https://ncbi.nlm.nih.gov/pubmed/21387465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.21491
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