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Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol
Dioxins are widespread environmental contaminants that induce the carcinogen-activating enzyme, cytochrome P450 1A1 (CYP1A1) through an aryl hydrocarbon receptor (AhR)-dependent mechanism. We previously demonstrated that harmine inhibits the dioxin-mediated induction of Cyp1a1 activity in murine hep...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3263333/ https://ncbi.nlm.nih.gov/pubmed/22001777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2011.09.030 |
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