Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol

Dioxins are widespread environmental contaminants that induce the carcinogen-activating enzyme, cytochrome P450 1A1 (CYP1A1) through an aryl hydrocarbon receptor (AhR)-dependent mechanism. We previously demonstrated that harmine inhibits the dioxin-mediated induction of Cyp1a1 activity in murine hep...

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Bibliographic Details
Main Authors: El Gendy, Mohamed A.M., Soshilov, Anatoly A., Denison, Michael S., El-Kadi, Ayman O.S.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263333/
https://ncbi.nlm.nih.gov/pubmed/22001777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2011.09.030
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