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The p38 MAPK Inhibitor SB203580 Induces Cytochrome P450 1A1 Gene Expression in Murine and Human Hepatoma Cell lines through Ligand-Dependent Aryl Hydrocarbon Receptor Activation
We have previously shown that the p38 MAPK inhibitor SB203580 (SB) significantly induced the Cyp1a1 gene expression at the mRNA and activity levels, whereas dramatically inhibited the induction of Cyp1a1 by TCDD in murine hepatoma Hepa 1c1c7 cells. However, the molecular mechanisms involved were not...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3263331/ https://ncbi.nlm.nih.gov/pubmed/21732638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200141p |
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