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The 5α-androstanedione pathway to dihydrotestosterone in castration-resistant prostate cancer
The survival and progression of prostate cancer is generally dependent on expression of the androgen receptor (AR), as well as the availability of endogenous AR agonists. Originating from the gonads, testosterone is released into circulation and is converted by steroid-5α-reductase (SRD5A) in prosta...
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| Hlavní autor: | |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3262939/ https://ncbi.nlm.nih.gov/pubmed/22064602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.231/JIM.0b013e31823874a4 |
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