Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation

Persistent exposure to cognate antigen leads to the functional impairment and exhaustion of HIV-specific CD8 T cells. Antigen withdrawal, due either to antiretroviral treatment or the emergence of epitope escape mutations, causes HIV-specific CD8 T cell responses to wane over time. However, this pro...

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Bibliographische Detailangaben
Hauptverfasser: Janbazian, Loury, Price, David A., Canderan, Glenda, Filali-Mouhim, Abdelali, Asher, Tedi E., Ambrozak, David R., Scheinberg, Phillip, Boulassel, Mohamad Rachid, Routy, Jean-Pierre, Koup, Richard A., Douek, Daniel C., Sekaly, Rafick-Pierre, Trautmann, Lydie
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262882/
https://ncbi.nlm.nih.gov/pubmed/22210916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102610
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