Convergent recombination shapes the clonotypic landscape of the naïve T-cell repertoire

Adaptive T-cell immunity relies on the recruitment of antigen-specific clonotypes, each defined by the expression of a distinct T-cell receptor (TCR), from an array of naïve T-cell precursors. Despite the enormous clonotypic diversity that resides within the naïve T-cell pool, interindividual sharin...

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Autori principali: Quigley, Máire F., Greenaway, Hui Yee, Venturi, Vanessa, Lindsay, Ross, Quinn, Kylie M., Seder, Robert A., Douek, Daniel C., Davenport, Miles P., Price, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2984183/
https://ncbi.nlm.nih.gov/pubmed/20974936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010586107
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