Pharmacologic Suppression of Hepcidin Increases Macrophage Cholesterol Efflux and Reduces Foam Cell Formation and Atherosclerosis

OBJECTIVES: We recently reported that lowering of macrophage free intracellular iron increases expression of cholesterol efflux transporters ABCA1 and ABCG1 by reducing generation of reactive oxygen species. In this study, we explore whether reducing macrophage intracellular iron levels via pharmaco...

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Autors principals: Saeed, Omar, Otsuka, Fumiyuki, Polavarapu, Rohini, Karmali, Vinit, Weiss, Daiana, Davis, Talina, Rostad, Brad, Pachura, Kimberly, Adams, Lila, Elliott, John, Taylor, W. Robert, Narula, Jagat, Kolodgie, Frank, Virmani, Renu, Hong, Charles C., Finn, Aloke V.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262074/
https://ncbi.nlm.nih.gov/pubmed/22095982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.240101
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